Preprints
An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement.
Bouabid S*, Vu MT*, Noggle C, Vietti-Michelina S, Brimblecombe K, Platt N, Zhang L, Joshi A, Cragg S, Howe MW.
bioRxiv (2026) *These authors contributed equally to this work — code
Dynamic imbalances in cell-type specific striatal ensemble activity during visually guided locomotion.
Fearey B*, Tong Y*, Alexander A, Graham B, Howe M.
bioRxiv (2024) *These authors contributed equally to this work.
Publications
Striatum-wide dopamine encodes trajectory errors separated from value
Brown EH, Zi Y, Vu M-A, Bouabid S, Lindsey J, Godfrey-Nwachukwu C, Attarwala A, Litwin-Kumar A, DePasquale B, Howe MW.
Nature (2026) — preprint, data, code
Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations.
Bouabid S, Zhang L, Vu MT, Tang K, Graham BM, Noggle CA, Howe MW.
Nature Communications (2025) — preprint, data, code
Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior.
Vu M-AT, Brown EH, Wen MJ, Noggle CA, Zhang Z, Monk KJ, Bouabid S, Mroz L, Graham BM, Zhuo Y, Li Y, Otchy TM, Tian L, Davison IG, Boas DA, Howe MW.
Neuron (2024) — preprint, data
Resources: Multifiber Localization, Multifiber Data Processing
Editorial: Dopamine Neuron Diversity in Circuits and Diseases.
Poulin J-F, Lerner TN, Howe MW.
Frontiers in Neural Circuits (2022)
Coordination of rapid cholinergic and dopaminergic signaling in striatum during spontaneous movement.
Howe M, Ridouh I, Allegra Mascaro AL, Larios A, Azcorra M, Dombeck DA.
Elife (2019)
Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors.
Patriarchi T, Cho JR, Merten K, Howe MW, Marley A, Xiong WH, Folk RW, Broussard GJ, Liang R, Jang MJ, Zhong H, Dombeck D, von Zastrow M, Nimmerjahn A, Gradinaru V, Williams JT, Tian L.
Science (2018)
Rapid signalling in distinct dopaminergic axons during locomotion and reward.
Howe MW, Dombeck DA.
Nature (2016)
Neurons in the ventral striatum exhibit cell-type-specific representations of outcome during learning.
Atallah HE, McCool AD, Howe MW, Graybiel AM.
Neuron (2014)
Prolonged dopamine signalling in striatum signals proximity and value of distant rewards.
Howe MW, Tierney PL, Sandberg SG, Phillips PEM, Graybiel AM.
Nature (2013)
Selective effects of dopamine depletion and L-DOPA therapy on learning-related firing dynamics of striatal neurons.
Hernandez LF, Kubota Y, Hu D, Howe MW, Lemaire N, Graybiel AM.
Journal of Neuroscience (2013)
Effects of dopamine depletion on LFP oscillations in striatum are task-and learning-dependent and selectively reversed by L-DOPA.
N Lemaire, LF Hernandez, D Hu, Y Kubota, MW Howe, AM Graybiel.
Proceedings of the National Academy of Sciences (2012)
Habit learning is associated with major shifts in frequencies of oscillatory activity and synchronized spike firing in striatum.
Howe MW, Atallah HE, McCool A, Gibson DJ, Graybiel AM.
Proceedings of the National Academy of Sciences (2011)
Differential dynamics of activity changes in dorsolateral and dorsomedial striatal loops during learning.
CA Thorn, H Atallah, M Howe, AM Graybiel
Neuron (2010)